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河北大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院劉保生研究生導(dǎo)師成永強介紹如下：

成永強，男，河北省定州市人，河北大學(xué)博士，教授，博士研究生導(dǎo)師。

研究方向：生化分析與生物傳感。研究工作發(fā)表在Angew. Chem. Int. Ed., Anal. Chem., Chem. Commun., ACS Appl. Mater. Interfaces, Analyst等期刊上。
獲2012年教育部全國優(yōu)秀博士學(xué)位論文提名獎；獲2012年河北省優(yōu)秀博士學(xué)位論文；獲2010年河北省自然科學(xué)獎一等獎（2010ZR1002-3）；2017年河北省自然科學(xué)獎二等獎（2017ZR2001-2）。

聯(lián)系方式：E-mail：yqcheng@hbu.edu.cn； yqcheng@126.com

一、主講課程：儀器分析、儀器分析實驗、分子光譜分析

二、研究內(nèi)容：

1、核酸和蛋白質(zhì)等生物大分子檢測新方法新技術(shù)研究；

2、細胞、細菌識別、成像及殺傷新材料新方法研究。

三、主持科研項目

1. 國家自然科學(xué)基金(21475031)，DNA水凝膠-陽離子共軛聚合物雜化熒光納米粒子的制備及其應(yīng)用于腫瘤細胞成像與治療研究，2015年-2018年；

2. 河北省自然科學(xué)基金(B2012201078)，滾環(huán)擴增RNA適配體無標記熒光成像原位檢測microRNA，2012年-2014年；

3. 國家自然科學(xué)基金(21075028)，恒溫擴增高通量高靈敏度熒光成像檢測microRNA 的研究，2011年-2013年；

4. 教育部高等學(xué)校博士學(xué)科點基金(20091301120003)，基于滾環(huán)擴增的microRNA 原位、高通量分析，2010年-2012年；

5. 河北省自然科學(xué)基金(B2009000170)，滾環(huán)擴增共軛聚合物熒光共振能量轉(zhuǎn)移高靈敏度檢測核酸的研究，2009年-2011年

四、代表性論文：

1. Yongqiang Cheng,* Lijuan Dong, Jiangyan Zhang, Yaqing Zhao, and Zhengping Li,* Recent advances in microRNA detection, Analyst, 2018, 143, 1758-1774.

2. Jingxiao Tian, Jiangyan Zhang, Jiangtao Yang, Lingyun Du, Hao Geng, and Yongqiang Cheng,* Conjugated Polymers Act Synergistically with Antibiotics to Combat Bacterial Drug Resistance, ACS Appl. Mater. Interfaces, 2017, 9, 18512-18520.

3. Yacui Liu, Jiangyan Zhang*, Jingxiao Tian, Xiaofei Fan, Hao Geng, Yongqiang Cheng*, Multiplex detection of microRNAs by combining molecular beacon probes with T7 exonuclease-assisted cyclic amplification reaction, Anal. Bioanal. Chem., 2017, 409, 107-114.

4. Likun Zhao, Jiangyan Zhang,* Huiming Xu, Hao Geng, and Yongqiang Cheng*, Conjugated Polymers/DNA Hybrid Materials for Protein Inactivation, ACS Appl. Mater. Interfaces, 2016, 8, 22923−22929.

5. Yuanyuan Zhou, Jiangyan Zhang, Likun Zhao, Yingcun Li, Hui Chen, Shengliang Li, and Yongqiang Cheng*, Visual Detection of Multiplex MicroRNAs Using Cationic Conjugated Polymer Materials, ACS Appl. Mater. Interfaces, 2016, 8, 1520-1526.

6. Yingcun Li, Jiangyan Zhang,* Jingjing Zhao, Likun Zhao, Yongqiang Cheng* and Zhengping Li, A simple molecular beacon with duplex-specific nuclease amplification for detection of microRNA, Analyst, 2016, 141, 1071-1076.

7. Zheng Yuan, Yuanyuan Zhou, Shuxin Gao, Yongqiang Cheng*, and Zhengping Li*, Homogeneous and Sensitive Detection of microRNA with Ligase Chain Reaction and Lambda Exonuclease-Assisted Cationic Conjugated Polymer Biosensing, ACS Appl. Mater. Interfaces, 2014, 6, 6181-6185.

8. Yongqiang Cheng*, Jingjing Zhao, Hailian Jia, Zheng Yuan and Zhengping Li*, Ligase chain reaction coupled with rolling circle amplification for high sensitivity detection of single nucleotide polymorphisms, Analyst, 2013, 138, 2958-2963.

9. Yongqiang Cheng*, Qing Du, Liyong Wang, Hailian Jia, and Zhengping Li*, Fluorescently Cationic Conjugated Polymer as an Indicator of Ligase Chain Reaction for Sensitive and Homogeneous Detection of Single Nucleotide Polymorphism, Analytical Chemistry, 2012, 84, 3739-3744.

10. Liyong Wang, Yongqiang Cheng,* Hui Wang, Zhengping Li*, A Homogeneous Fluorescence Sensing Platform with Water-soluble Carbon Nanoparticles for Detection of MicroRNA and Nuclease Activity, Analyst, 2012, 137, 3667-3672.

11. TANG ZhiYuan, CHENG YongQiang*, DU Qing, ZHANG HongXia & LI ZhengPing*, Integration of rolling circle amplification and cationic conjugated polymer for the homogeneous detection of single nucleotide polymorphisms, Chinese Science Bulletin, 2011, 56, 3247-3252.

12. Yongqiang Cheng, Xian Zhang, Zhengping Li, Xiaoxia Jiao, Yucong Wang, and Yali Zhang, Highly Sensitive Determination of microRNA Using Target-Primed and Branched Rolling-Circle Amplification, Angew. Chem. Int. Ed., 2009, 48, 3268-3272.

13. Yongqiang Cheng, Zhengping Li, Baoan Du, and Xian Zhang, Homogeneous and label-free bioluminescence detection of single nucleotide polymorphism with rolling circle amplification, Analyst, 2008, 133, 750-752.

14. Yongqiang Cheng, Zhengping Li, Xian Zhang, Baoan Du, Yongshan Fan, Homogeneous and label-free fluorescence detection of single-nucleotide polymorphism using target-primed branched rolling circle amplification, Anal. Biochem., 2008, 378，123-126.

15. Yongqiang Cheng, Zhengping Li, Yuqin Su, Yongshan Fan, Ferric nanoparticle-based resonance light scattering determination of DNA at nanogram levels, Talanta, 2007, 71, 1757-1761.