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西南大學生命技術學院教授簡介－－三田和英
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http://swjsxy.swu.edu.cn/viscms/u/cms/swjsxy/201505/29162020f3sk.jpg 家蠶基因組生物學國家重點實驗室教授 國家“外專千人計劃”特聘專家 研究方向： 家蠶W染色體分析、性別決定級聯研究、家蠶進化研究、斜紋夜蛾基因組測序。 科學成就： 三田和英教授，為國家“外專千人計劃”特聘專家。曾任日本國立農業生物科學研究所昆蟲基因組單元負責人、特別高級研究員，主持家蠶基因項目及注釋項目，作為日本家蠶基因組計劃的負責人領導日本家蠶基因研究團隊開展家蠶基因組計劃，構建了家蠶30萬條EST數據庫及BAC文庫，并利用shotgun技術獲得3倍深度的家蠶基因組數據構建家蠶全長cDNA文庫構建和大規模測序分析，掌握了迄今為止世界最高質量和數量的全長cDNA數據庫。此外，三田和英教授還在家蠶數據庫構建、性別決定機制、人工選擇進化、轉基因、免疫及抗性等多個領域做出了重要貢獻，取得了眾多的高水平成果。近年在PNAS, Nucleic Acids Research, DNA research, J Biol Chem, Genetics等國際學術刊物上發表高水平論文200余篇；同時，在多個國際學術組織及雜志如美國細胞生物學學會、日本分子生物學學會、日本蠶業科學學會、BMC基因組學、BMC發育生物學、基因、昆蟲分子生物學、昆蟲生理學等國際知名雜志擔任要職。 教育經歷： 1970.4 -1975.3: 日本京都大學，博士，高分子化學，主要從事聚電解質溶液的物理化學研究 1966.4-1970.3: 日本京都大學，學士，高分子化學 工作經歷： 1975-1993: 日本國立放射科學研究所研究員，從事染色質結構研究； 1994-2001.3: 日本國立放射科學研究所DNA測序及生物信息學方向負責人，領導分裂酵母的cDNA目錄及基因組測序項目。自1997年起，與Maeda博士（加州大學戴維斯分校）及島田博士（東京大學）啟動了家蠶基因項目； 2001.4-2006.3: 日本國立農業生物科學研究所昆蟲基因組實驗室主任，主持家蠶基因組項目； 2006.4-2008.3: 日本國立農業生物科學研究所昆蟲基因組單元負責人，主持家蠶基因組項目； 2008.4-2013.2: 日本國立農業生物科學研究所、特別高級研究員，主持家蠶基因項目及注釋項目； 2013.3-至今: 家蠶基因組生物學國家重點實驗室，國家“外專千人計劃”特聘專家。 獲得榮譽： 1. 2005 榮獲日本蠶業科學協會“家蠶基因組分析”特別榮譽 2. 2011 榮獲國際蠶業委員會路易牧場獎 3. 2012 中國國家“外專千人計劃”特聘專家 4. 2015 榮獲重慶市外國專家“重慶友誼獎” 代表性論文： 1. Ravikumar Gopalapillai*, Keiko Kadono-Okuda, Kozo Tsuchida+, Kimiko Yamamoto, Junko Nohata, Masahiro Ajimura and Kazuei Mita (2006) Lipophorin receptor from the silkworm, Bombyx mori: cDNA cloning, genomic structure, alternative splicing and isolation of a new isoform. J. Lipid Res. 47, 1005-1013. 2. Yamamoto, K., Narukawa, J., Kadono-Okuda, K., Nohata, J., Sasanuma, M., Suetsugu, Y., Banno, Y., Fujii, H., Goldsmith, M.R. and Mita, K. (2006) Construction of a Single Nucleotide Polymorphism Linkage Map for the Silkworm, Bombyx mori, Based on BAC End-sequences. Genetics 173, 151-161. 3. Katsuma, S., Daimon, T., Mita, K. and Shimada, T. (2006) Lepidopteran ortholog of Drosophila Breathless is a receptor for the baculoviral fibroblast growth factor. J. Virol. 80, 5474-5481. 4. Negre V, Hotelier T, Volkoff AN, Gimenez S, Cousserans F, Mita K, Sabau X, Rocher J, Lopez-Ferber M, d'Alencon E, Audant P, Sabourault C, Bidegainberry V, Hilliou F, Fournier P (2006) SPODOBASE : an EST database for the lepidopteran crop pest Spodoptera. BMC Bioinformatics 7, 322-331. 5. Yonemura N, Sehnal F, Mita K, Tamura T. (2006) Protein composition of silk filaments spun under water by caddisfly larvae. Biomacromolecules 7, 3370-3378. 6. Abe H, Fujii T, Tanaka N, Yokoyama T, Kakehashi H, Ajimura M, Mita K, Banno Y, Yasukochi Y, Oshiki T, Nenoi M, Ishikawa T, Shimada T (2008) Identification of the female-determining region of the W chromosome in Bombyx mori. Genetica 133, 269-282.. 7. Takasu Y, Yamada H, Tamura T, Sezutsu H, Mita K, Tsubouchi K. (2007) Identification and characterization of a novel sericin gene expressed in the anterior middle silk gland of the silkworm Bombyx mori. Insect Biochem Mol Biol. 37,1234-40. 8. Shinpei Kawaoka, Kosuke Minami, Susumu Katsuma, Kazuei Mita, and Toru Shimada (2008) Developmentally synchronized expression of two Bombyx mori Piwi subfamily genes, SIWI and BmAGO3 in germ-line cells. Biochem. Biophys. Res. Commun. 367(4): 755-760. 9. Yamamoto K, Nohata J, Kadono-Okuda K, Narukawa J, Sasanuma M, Sasanuma S, Minami H, Shimomura M, Suetsugu Y, Banno Y, Osoegawa K, de Jong P, Goldsmith MR, Mita K. (2008) A BAC-based integrated linkage map of the silkworm, Bombyx mori. Genome Biology 9: R21. 10. Noda H, Kawai S, Koizumi Y, Matsui K, Zhang Q, Furukawa S, Shimomura M, Mita K. (2008) Annotated ESTs from various tissues of the brown planthopper Nilaparvata lugens: a genomic resource for studying agricultural pests. BMC Genomics 9:117. 11. Ito K, Kidokoro K, Sezutsu H, Nohata J, Yamamoto K, Kobayashi I, Uchino K, Kalyebi A, Eguchi R, Hara W, Tamura T, Katsuma S, Shimada T, Mita K, Kadono-Okuda K. (2008) Deletion of a gene encoding an amino acid transporter in the midgut membrane causes resistance to a Bombyx parvo-like virus. Proc. Natl. Acad. Sci. USA 105: 7523-7527. 12. Daimon T, Taguchi T, Meng Y, Katsuma S, Mita K, Shimada T. (2008) beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. J. Biol. Chem. 283: 15271-15279. 13. Okamoto S, Futahashi R, Kojima T, Mita K, Fujiwara H. (2008) A catalogue of epidermal genes: genes expressed in the epidermis during larval molt of the silkworm Bombyx mori. BMC Genomics 9: 396. 14. Kawaoka S, Hayashi N, Katsuma S, Kishino H, Kohara Y., Mita K, Shimada T. (2008) Bombyx small RNAs: Genomic defense system against transposons in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1058-1065. 15. Tanaka H, Ishibashi J, Fujita K, Nakajima Y, Sagisaka A, Tomimoto K, Suzuki N, Yoshiyama M, Kaneko Y, Iwasaki T, Sunagawa T, Yamaji K, Asaoka A, Mita K, Yamakawa M. (2008) A genome-wide analysis of genes and gene families involved in innate immunity of Bombyx mori. Insect Biochem Mol Biol. 38: 1087-1110. 16. Futahashi R, Sato J, Meng Y, Okamoto S, Daimon T, Yamamoto K, Suetsugu Y, Narukawa J, Takahashi H, Banno Y, Katsuma S, Shimada T, Mita K, Fujiwara H. (2008) yellow and ebony are the Responsible Genes for the Larval Color Mutants of the Silkworm Bombyx mori. Genetics 180: 1995-2005, 17. The International Silkworm Genome Consortium. (2008) The genome of a lepidopteran model insect, the silkworm Bombyx mori. Insect Biochem. Mol. Biol. 38: 1036-1045. 18. Osanai-Futahashi M, Suetsugu Y, Mita K, Fujiwara H. (2008) Genome-wide screening and characterization of transposable elements and their distribution analysis in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1046-1057. 19. Futahashi R, Okamoto S, Kawasaki H, Zhong Y, Iwanaga M, Mita K, Fujiwara H. (2008) Genome-wide identification of cuticular protein genes in the silkworm, Bombyx mori. Insect Biochem. Mol. Biol. 38: 1138-1146. 20. Zou Z, Picheng Z, Weng H, Mita K, Jiang H. (2009) A comparative analysis of serpin genes in the silkworm genome. Genomics 93: 367-375. 21. Meng Y, Katsuma S, Daimon T, Banno Y, Uchino K, Sezutsu H, Tamura T, Mita K, Shimada T. (2009) The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. J. Biol. Chem. 284: 11698-11705. 22. Arunkumar, K.P., Mita, K., Nagaraju, J. (2009) Silkworm Z chromosome is enriched in testis-specific genes. Genetics 182: 493-501. 23. Yonemura N, Mita K, Tamura T, Sehnal F. (2009) Conservation of Silk Genes in Trichoptera and Lepidoptera. J. Mol. Evol. 68: 641-653. 24. Shimomura M, Minami H, Suetsugu Y, Ohyanagi H, Satoh C, Antonio B, Nagamura Y, Kadono-Okuda K, Kajiwara H, Sezutsu H, Nagaraju J, Goldsmith MR, Xia Q, Yamamoto K, Mita K. (2009) KAIKObase: An integrated silkworm genome database and data mining tools. BMC Genomics 10: 486. 25. Ito K, Katsuma S, Yamamoto K, Kadono-Okuda K, Mita K, Shimada T. (2010) Yellow-E determines the color pattern of larval head and tail spots of the silkworm, Bombyx mori. J. Biol. Chem. 285: 5624-5629. 26. d’Alençon E, Sezutsu H, Legeai F, Permal E, Bernard-Samain S, Gimenez S, Gagneur C, Cousserans F, Shimomura S, Brun-Barale A, Flutie T, Couloux A, East P, Gordon K, Mita K, Quesneville H, Fournier P, Feyereisen R. (2010) Extensive synteny conservation of holocentric chromosomes in Lepidoptera despite high rates of local genome rearrangements. Proc. Natl. Acad. Sci. USA 107: 7680-7685. 27. Liu C, Yamamoto K, Cheng T, Okuda-Kadono K, Narukawa J, Liu S, Han Y, Noda H, Kobayashi I, Futahashi R, Tamura T, Ohnuma A, Banno Y, Dai F, Xiang Z, Goldsmith MR, Mita K, Xia Q. (2010) Repression of tyrosine hydroxylase caused the sex-linked chocolate mutation of the silkworm, Bombyx mori. Proc. Natl. Acad. Sci. USA 107: 12980-12985. 28. Suetsugu Y, Futahashi R, Kanamori H, Kadono-Okuda K, Sasanuma S, Narukawa J, Ajimura M, Jouraku A, Namiki N, Shimomura M, Sezutsu H, Osanai-Futahashi M, Suzuki M, Daimon T, Shinoda T, Taniai K, Asaoka K, Niwa R, Kawaoka S, Katsuma S, Tamura T, Noda H, Kasahara M, Sugano S, Suzuki Y, Fujiwara H, Kataoka H, Arunkumar K, Tomar A, Nagaraju J, Goldsmith M R, Feng Q, Xia Q, Yamamoto K, Shimada T, and Mita K (2013) Large Scale Full-Length cDNA Sequencing Reveals a Unique Genomic Landscape in a Lepidopteran Model Insect, Bombyx mori. G3 3: 1481-1492. 聯系方式：400716，西南大學 家蠶基因組生物學國家重點實驗室 電 話：+86-23-6825 1683 傳 真：+86-23-68251128 E-mail: mitakazuei@gmail.com |
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